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KMID : 1103720110650010027
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Journal of the Korean Society of Radiology
2011 Volume.65 No. 1 p.27 ~ p.33
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Clinical Utility of Iopamidol (Pamiray®370) for Cardiac CT
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Kim Mok-Hee
Choi Song
Sun Hyun-Ju
Kim Yun-Hyun
Kim Jae-Kyu
Park Jin-Gyoon
Kang Heoung-Keun
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Abstract
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Purpose: We evaluated the utility of iopamidol-based nonionic contrast media (Pamiray®370) for cardiac CT, with assessment of its image quality and safety.
Materials and Methods: The study included 100 patients who underwent cardiac CT with Pamiray®370 (experimental group), and 100 patientswho underwent cardiac CT with Ultravist®370 (control group). A comparison of the image qualities and degree of vascular contrast enhancement was made between the two groups and evaluated statistically by an independent t-test. Changes in vital signs and adverse events during cardiac CT were evaluated in the experimental group.
Results: There were no statistically significant differences in the image quality (image quality score in experimental group vs. control group: 4.26 ± 0.63 vs. 4.24 ± 0.62), and mean attenuation values at the coronary arteries(p > 0.05) between two groups. For the experimental group, 12% experienced adverse events, including mild and transient reactions such as dizziness (7%), nausea (4%), and fatigue (1%). Further, 94% of patients complained of mild to moderate febrile sense just after contrast agent administration, which spontaneously disappeared within 3 minutes without any specific management.
Conclusion:For cardiac CT, Pamiray®370 was comparable to the widely-used contrast agent (Ultravist®370) in terms of image quality and safety without any severe adverse reaction.
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KEYWORD
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Computed Tomography, X-ray , Contrast Media , Heart , Coronary Vessels
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